According to new data by the ever-looming NPD group, Guitar Hero III: Legends of Rock is at the top of the current leaderboard of lifetime sales for any game in recent history.
Call of Duty, Nintendo, and Viacom complete the rest of the Top 10.
1. Guitar Hero III: Legends of Rock
2. Call of Duty: Black Ops
3. Wii Fit
4. Call of Duty: Modern Warfare 2
5. Rock Band
6. Wii Play (with remote)
7. Guitar Hero World Tour
8. Wii Fit Plus
9. Mario Kart (with Wheel)
10. Call of Duty 4: Modern Warfare
This list does not include games bundled with video game systems like Super Mario World, Super Mario Bros. 3, and Wii Sports. Nor does it changes in inflation.
[Source]